Biological Systems Modeling

There is growing recognition that the emergent, integrative behaviors of biological systems are a result of complex interactions between all the components from which these systems are composed and that knowledge of each system component, however detailed, is not sufficient by itself to understand these integrative behaviors.

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Computational Anatomy

Computational Anatomy (CA) is emerging as a discipline focused on the quantitative analysis of variability of biological shape.  Although the study of biological shapes can be traced to the beginnings of modern science, in his influential treatise "On Growth and Form'' in 1917, D'Arcy Thompson had the clearest vision of what lay ahead, in which shapes are modeled as an orbit under groups of mathematical shape transformations.

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Bioinformatics

Biomedical research is being revolutionized by new technologies for generating high throughput data.  For example, the mRNA counts contained in gene microarrays provide a global view of cellular activity by simultaneously recording the expression levels of thousands of genes. Similarly, new methods for measuring the expression of proteins in cells and tissues and mapping protein-protein interactions are providing rich sources of information for learning about disease mechanisms. Research in bioinformatics at the ICM is currently focused on representing and analyzing such data.

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