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Dr. Rachel Karchin receives $839K grant from NCI

Date: September 23, 2013

Dr. Rachel Karchin, Associate Professor in the Department of Biomedical Engineering and Institute for Computational Medicine, has received funding for a new research project cooperative agreement from the Informatics Technology for Cancer Research Initiative (ITCR) of the National Cancer Institute. The mission of the ITCR is “to support innovative investigator-initiated research-driven informatics technology development to improve the acquisition, management, analysis, and dissemination of data and knowledge in the investigation and management of cancer.”

The grant, entitled “Informatics Tools for High-throughput Analysis of Cancer Mutations”, provides $839K for three years and will facilitate development of the Cancer-Related Analysis of VAriants Toolkit (CRAVAT), a web- and cloud-based service for high-throughput exploration of tumor sequencing results. CRAVAT analysis identifies mutations most likely to have deleterious impact on protein function and those that are most likely to confer a selective advantage to cancer cells (drivers), using classifiers developed by the Karchin team. The work will contribute to understanding of the genetic complexity and heterogeneity of tumors and assist in discovery of new approaches for cancer prognosis and treatment. This new funding will also further support the long-standing collaboration between the Karchin Lab and In Silico Solutions, a bioinformatics software company in Fairfax, VA.


Dr. Tilak Ratnanather and Daniel Tward honored for Medical Physics paper with Farrington Daniels Award

Date: September 20, 2013

Daniel Tward receives award from AAPM
Daniel Tward receives award from AAPM
The American Association of Physicists in Medicine (AAPM) have selected the best paper published in Medical Physics in 2012 — “Effects of protocol and obesity on dose conversion factors in adult body CT.” This honor will be marked with receipt of the prestigious Farrington Daniels Award, which is bestowed yearly to the authors of the most outstanding paper on radiation dosimetry.

Johns Hopkins biomedical engineering authors Tilak Ratnanather, D.Phil, and graduate student Daniel Tward were presented with the award in a ceremony on August 5, 2013, in Indianapolis, IN. In the paper the researchers concluded that obesity has a significant effect on computed tomography dose and risk conversion coefficients — which cannot be predicted using body diameter alone — and that size-specific dose estimates generally overestimate organ dose for obese patients.

Congratulations!

 


Drs. Natalia Trayanova and Patrick Boyle to appear on "Maryland Morning" Monday, 9/23

Date: September 19, 2013

The Institute for Computational Medicine’s Dr. Natalia Trayanova, Murray B. Sachs Professor of Biomedical Engineering, and Dr. Patrick Boyle, Postdoctoral Fellow, will be interviewed during the Monday, September 23rd episode of Maryland Morning with Sheilah Kast on WYPR, 88.1 FM. The interview will focus on research by the Trayanova lab published in the August 28 issue of Nature Communications, entitled, "A comprehensive multiscale framework for simulating optogenetics in the heart".

The segment by Drs. Trayanova and Boyle is scheduled for 9:08 a.m. The broadcast will also be streamed live at http://www.wypr.org/

Update: An audio segment is posted along with a write-up on the Maryland Morning Website here.

Information on previous press coverage of the Nature Communications journal article can be found here.


Kelly Chang to be first recipient of David C. Gakenheimer Fellowship award

Date: September 17, 2013

Kelly Chang, a Graduate Student in the lab of Dr. Natalia Trayanova, Murray B. Sachs Professor of Biomedical Engineering and member of the Institute for Computational Medicine, has been selected as the first recipient of the Institute for Computational Medicine’s David C. Gakenheimer Fellowship, for the 2013-2014 academic year.

Dr. Gakenheimer, who holds a bachelor’s degree in engineering mechanics from Johns Hopkins University, generously funded this fellowship to provide support to a student conducting heart research in developing and advancing diagnostic methods such as detection, classification and treatment of rhythm disorders.

Congratulations to Kelly and good luck with your research!


Research from Dr. Trayanova's lab published in Nature Communications and featured on JHU News site

Date: August 28, 2013

Dr. Natalia Trayanova, Murray B. Sachs Professor of Biomedical Engineering and member of the Institute for Computational Medicine was featured in a recent news release on the Johns Hopkins University News website. The article, entitled “Researchers Aim to Use Light—Not Electric Jolts—to Restore Healthy Heartbeats” was released on August 28 along with publication of the research in Nature Communications.

“In a paper published today in the online journal Nature Communications, five biomedical engineers from Johns Hopkins and Stony Brook universities described their plan to use biological lab data and an intricate computer model to devise a better way to heal ailing hearts. Other scientists are already using light-sensitive cells to control certain activities in the brain. The Johns Hopkins-Stony Brook researchers say they plan to give this technique a cardiac twist so that doctors in the near future will be able to use low-energy light to solve serious heart problems such as arrhythmia.”

To read the full story, click here.

** Update: November 19 ** The story was featured in the Baltimore Sun here: Light could replace shock to regulate hearts

U.S. and international coverage:

Slate Magazine, Aug. 30: Future Heart Attack Treatments Will Use Light, Not Volts, to Keep Your Heart Beating
CNET News (CBS Interactive), Aug. 28: Scientists shine a light on irregular heart beats
BioOptics World, Aug. 30: Optogenetics could work to correct life-threatening arrhythmias
Diagnostic and Interventional Cardiology, Sept. 6: Researchers Aim to Use Light — Not Electric Jolts — to Restore Healthy Heartbeats
Motherboard, Aug. 30: The Pacemakers of the Future Will Keep Your Heart Beating With Light
GMA News (The Philippines), Aug. 30: US researchers eye light beams to treat irregular heartbeats
Ivanhoe’s Medical Breakthroughs, Sep. 3: Using Light Instead of Electric Jolts to Restore Heartbeats
Medgadget, Aug. 28: Virtual Heart Beats to the Rhythm of the Light
Zimbabwe Star, Aug. 31: Light-based technology rather than electric jolts may in future restore healthy heartbeats
eldeber.com.bo (Bolivia), Sept. 2: Usarán luz para estimular el corazón que late con arritmia
topsante.com (France), Sept. 2: Infarctus : de la lumière pour ranimer le cœur
elektroda.pl (Poland), Sept. 1: Światło zamiast impulsów elektrycznych w defibrylatorach przyszłości
Maxisciences.com (France), Sept. 1: Coeur : utiliser de la lumière en guise de défibrillateur
Scientific Computing, Sept. 3: Using Light — Not Electric Jolts — to Restore Healthy Heartbeats
HaziPatika.com (Hungary), Sept. 3: Újraélesztés: már fénnyel is lehetséges?
Big News Network (Australia), Aug. 29: Light could replace electric jolts to restore healthy heartbeats
Hot Digital News, Aug. 28: Scientists shine a light on irregular heart beats
OverclockersClub.com, Aug. 29: Potentially Replacing Electricity with Light for Pacemakers and Defibrillators
ThirdAge.com, Aug. 29: A New Kind of Defibrillator On the Horizon
Headlines & Global News, Aug. 28: Researchers Working on Technology to Replace ‘Electric Current’ with ‘Light’ to Restore Heartbeat
ANI News Service (India), Aug. 29: Light could replace electric jolts to restore healthy heartbeats
Toronto Telegraph, Aug. 29: Light could replace electric jolts to restore healthy heartbeats
R&D Magazine, Aug. 28: Researchers aim to use light to restore healthy heartbeats
Science Daily, Aug. 28: Researchers Aim to Use Light -- Not Electric Jolts -- To Restore Healthy Heartbeats
Zee News (India), Aug. 29: Light could replace electric jolts to restore healthy heartbeats
(Other India-based news sites that picked up this ANI article included Yahoo! News – India, NewKerala.com, WebIndia123.com, Truthdive.com, NewsTrackIndia.com, NewsSmashits.com, NetIndia123.com)

More coverage

Science Codex | Bioportfolio.com | ECN Magazine (Electronic Design Community): | News-Medical.Net | e! Science News | Press-News.org | Science Blog | ElectronicProducts.com | VR Zone.com | Futurity | Photonics.com | BioOptics World | Clubhouse News | AlwaysResearching.com | Bloggero.Info.com | Newswise | PT Community | Science Newsline | Laboratory Equipment | Eurekalert | Partner in Sublime | Lukor.Net | Baltimore Fishbowl | SmartBrief.com | MediLexicon | DPA on the Net | First World Med Tech | Medical News Today | Real Clear Science | AZ o Optics | DC-epaper | MDT Magazine | JHU Whiting School of Engineering News | Johns Hopkins Biomedical Engineering News


Dr. Natalia Trayanova's Research Featured in Johns Hopkins Children's Center News

Date: August 22, 2013

Dr. Natalia Trayanova, Murray B. Sachs Professor of Biomedical Engineering and member of the Institute for Computational Medicine was featured in a recent news release on the Johns Hopkins Children's Center website. The article, entitled “‘Virtual Heart’ Precision-Guides Defibrillator Placement in Children with Heart Disease” describes the Trayanova lab's groundbreaking research in pediatric cardiology. The lab seeks to remove the guesswork from the process of placing defibrillators on children born with heart defects through the use of 3-D virtual heart models.

The full story can be read on the hopkinschildrens.org website.

This story has also been featured in: Johns Hopkins Medicine News | JHU Biomedical Engineering News


Hermenegild Arevalo as finalist for Young Investigator Competition at ICE 2013

Date: August 19, 2013

Hermenegild Arevalo, a PhD student in the lab of Dr. Natalia Trayanova, was chosen as one of the finalists in the Young Investigator Competition at the 2013 International Congress on Electrocardiology held in Glasgow, Scotland from August 7-10. This honor is an amazing achievement for Hermenegild, who was competing against applicants from all over the world.

At the conference, Hermenegild presented his recent study, "Patient-Specific MRI-Based Models of Infarcted Hearts Can Predict Risk of Sudden Cardiac Death". For more information on the meeting, visit the ICE 2013 website here.

Congratulations Hermenegild!


University launches The Johns Hopkins Individualized Health Initiative (Hopkins inHealth)

Date: August 6, 2013

The Johns Hopkins Individualized Health Initiative (Hopkins inHealth) aims to develop and implement novel methods and tools to intelligently use information to individualize wellness, early disease detection, and more effective and affordable treatment. It is a University-wide, collaborative venture that is both visionary and pragmatic. The initiative builds on dramatic advances over recent years in biological research, in new technologies that afford an increasingly detailed view of disease, and in computational and data sciences. ICM is delighted that three members of our core faculty have been recruited to participate in the initiative and help advance its goals. Dr. Raimond Winslow, Raj and Neera Singh Professor, Department of Biomedical Engineering and Director for the Institute for Computational Medicine is a member of the Hopkins inHealth Steering Committee, which will meet monthly to guide progress made by the Hopkins inHealth team, investigators, pilot projects, and cores. ICM faculty members Dr. Rachel Karchin, Associate Professor of the Department of Biomedical Engineering, and Dr. Suchi Saria, Assistant Professor in the Computer Science Department in the Whiting School of Engineering and in Health Policy and Management in the Bloomberg School of Public Health, have also been called upon by the inHealth initiative for their respective expertise in the field of “individualized medicine”.

To learn more about Hopkins inHealth, click here, or go directly to information about contributions to the initiative by Dr. Karchin and Dr. Saria.


Sabato Santaniello receives 2 year $150k award from National Science Foundation

Date: July 25, 2013

Sabato Santaniello, a scientist in the lab of Dr. Sridevi Sarma, Assistant Professor at the Institute for Computational Medicine, recently received an award of $150K for 2 years from the National Science Foundation. The award, which is part of the NSF's "Energy, Power, and Adaptive Systems" program is entitled "EAGER: Modeling Network Dynamics in the Epileptic Brain to Develop Translational Tools for Seizure Localization and Detection". The study is a collaboration with the Epilepsy Center at JHMI.

From the Grant abstract:

"Epilepsy affects 60 million people worldwide who suffer from recurrent seizures, and 40% of patients do not respond to any drug therapy. These patients would greatly benefit from closed-loop neurostimulation therapy to suppress seizures, but the efficacy of such therapy critically depends on whether the stimulus is administered close to the seizure origin (epileptogenic zone, EZ) and immediately prior to or at seizure onset. This program develops novel computational tools for effective EZ localization and seizure onset detection from multi-channel intracranial EEG (iEEG) recordings."

More details can be found about the award on the NSF website here.

Congratulations Sabato!


Dr. Natalia Trayanova's Research Featured in SIAM Connect News Site

Date: July 22, 2013

Dr. Natalia Trayanova, Murray B. Sachs Professor of Biomedical Engineering and member of the Institute for Computational Medicine was featured in "SIAM Connect", The Society for Industrial and Applied Mathematics' news site. The article, The beat goes on: Modeling the human heart is under the rubric "Explaining Applied Math Research", and is based on the keynote address Dr. Trayanova delivered at the Annual AiAM meeting in Boston earlier this year. A brief video overview of her talk and an interview with Dr. Trayanova conducted after her keynote lecture can be found here.



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