Raimond L. Winslow
Professor, Department of Biomedical Engineering
Director, Institute for Computational
Medicine
Director, Center for
Cardiovascular Bioinformatics and Modeling
Joint Appointment:
Department
of Medicine, The Johns Hopkins University School of
Medicine
Department of Electrical
and Computer Engineering
Division of Health
Sciences Informatics
Department of Computer
Science
Address:
3400 N. Charles Street
Computational Science & Engineering Building, Room 315
Baltimore, MD 21218
Phone: (410) 516-5417
Fax: (410) 516-5294
E-mail: rwinslow@jhu.edu
CV
Research Interest Statement
Computational modeling of intracellular signaling, metabolism
and electrical excitability in cardiac myocytes
Integrative modeling of cardiac function in health and
disease
Applications of machine learning methods to multi-scale
biomedical data analysis
Biomedical data representation and database design
Grid-computing and data-sharing
Current Projects
Biomedical Engineering Training Program
The Physiologic Genomics of Heart Failure
Calcium Cycling and Regulation of the Cardiac AP
Anatomical Remodeling and Electrical Conduction in Heart
Expression Profiling in Canine Models of Cardiopulmonary
Disease
The Johns Hopkins University – NHLBI Proteomics
Center
SCCOR: Ventilator-Associated Lung Injury: Molecular Approaches
Pathobiology of Cardiac Dyssynchrony & Resynchronization
Mitochondrial Function in Ischemic Heart Disease
Publications
Xu L., A.C. Tan, R.L. Winslow, D. Geman (2008). "Merging microarray data from separate breast cancer studies provides a robust prognostic test." BMC Bioinformatics, 9(125): 1471-2105.
Anderson T. J., I. Tchernyshyov, R. Diez, R. N. Cole, D. Geman, C. V. Dang, R. L. Winslow (2007). "Discovering robust protein biomarkers for disease from relative expression reversals in 2-D DIGE data." Proteomics, 7(8): 1197-207.
Tanskanen A. J., J. L. Greenstein, A. Chen, S. X. Sun, R. L. Winslow (2007). "Protein Geometry and Placement in the Cardiac Dyad Influence Macroscopic Properties of Calcium-Induced Calcium Release." Biophys J, 92(10): 3379-3396.
Xu L., D. Geman, R. L. Winslow (2007). "Large-scale integration of cancer microarray data identifies a robust common cancer signature." Bioinformatics, (8).
Gao Z., R. L. Winslow, G. Tomaselli (2007). "Key pathways responsible for heart failure development revealed by gene networks correlated with cardiac remodeling." Physiol. Genomics, (submitted).
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Presentations
Selected Presentations:
"Integrative Modeling of the Myocyte – Current Status and Future Direction." 4th International Symposium on the Mammalian Myocardium. Bristol, UK, July 17-20, 2005.
"An Integrative Model of the Cardiac Myocyte Incorporating Local Control of Ca2+ Release: Fast simulations using coupled channel models." 49th Biophysical Society Annual Meeting. Long Beach, CA, February 12-16, 2005.
"Multi-Scale Modeling of Cardiac Electrophysiological Function.” The Whitaker Foundation Biomedical Engineering Research Conference, August 12-15, 2004, La Jolla, CA.
"Ca-Induced Ca-Release in the Cardiac Myocyte: From Microscopic Channel Gating to Macroscopic Cell Behavior.” Pacific Northwest Symposium on Systems Biology, Richland WA, June 16-18, 2004
"Systems Biology: A Necessary Methodology for Understanding the Mechanisms of Sudden Cardiac Death in Heart Failure." 2003 Symposium on Systems Biology, The Institute for Systems Biology, Seattle WA, April 13-14, 2003
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