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Sridevi V. Sarma
Assistant Professor, Department of Biomedical Engineering
Institute for Computational Medicine
Address:
3400 N. Charles Street
Computational Science & Engineering Building, Room 316c
Baltimore, MD 21218
Phone: (410) 516-4183
Fax: (410) 516-5294
E-mail: ssarma2@jhu.edu
Research Interest Statement
Developing control-oriented input-output models of basal ganglia nuclei (BG) and motor thalamus that describe how deep brain stimulation waveforms (input) influence neuronal activity (output) from cells in BG nuclei and motor thalamus for Parkinson's disease (PD) patients; developing models of how neuronal activity in BG and motor thalamus influence PD patient behavior such as tremor frequency, movement velocity, and reaction time.
Designing feedback control algorithms that measure neuronal activity from one or more BG nuclei in a PD patient with DBS, and in turn select the appropriate DBS inputs to one or more BG nuclei to generate normal-like neural activity and behavior. These control strategies will be based on the input-output models developed above.
Developing point process models of single neurons in the sub-thalamic nucleus (STN) of the BG in PD patients that describe spiking characteristics across space and time. This information can be used to determine whether the neurophysiology in different regions of the STN varies, and whether some regions are more pathological than others-which may ultimately guide optimal DBS electrode placement.
Current Projects
- Closed-Loop Deep Brain Stimulation (DBS)
- Optimizing DBS Electrode Placement
- Automatic DBS Programming
Publications
Sarma S.V., M.A. Dahleh (2009). "Signal Reconstruction in the Presence of Finite-Rate Measurements: Finite-Horizon Control Applications." Journal on Robust and Nonlinear Control, (ePub Ahead of Print).
Sarma S.V., M.A. Dahleh (2007). "Remote Control Over Noisy Communication Channels: A First-Order Example." IEEE Transactions on Automatic Control, 52(2): 284-289.
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