Joseph L. Greenstein

Assistant Research Professor, Department of Biomedical Engineering
Center for Cardiovascular Bioinformatics and Modeling

Address:
3400 N. Charles Street
Computational Science & Engineering Building, Room 316b
Baltimore, MD 21218

Phone: (410) 516-5425
Fax: (410) 516-5294
E-mail: jgreenst@jhu.edu

CV

Research Interest Statement

Multi-scale Mathematical Modeling of the Cardiac Myocyte

Stochastic modeling of cardiac myocyte membrane ionic channels and excitation-contraction coupling. 

Development of efficient biophysically based models of local control of Ca2+-induced Ca2+ release in the cardiac myocyte (known as coupled models).

Incorporation of subcellular component models into integrative multi-scale models of the cardiac action potential for the study of mechanisms underlying integrated myocyte physiology in health and disease. 

Current Projects

The coupled LCC-RyR (L-type Ca2+ channel – Ryanodine Receptor) model of excitation-contraction coupling.

Investigation of the role of local redundancy in LCC gating on gain of excitation-contraction coupling.

Using spatially detailed myocyte models to understand the role of localization of ion channels, transporters, and signaling proteins to subcellular microdomains on integrative myocyte function.

Publications

Tanskanen A. J., J. L. Greenstein, A. Chen, S. X. Sun, R. L. Winslow (2007). "Protein Geometry and Placement in the Cardiac Dyad Influence Macroscopic Properties of Calcium-Induced Calcium Release." Biophys J, 92(10): 3379-3396.

Winslow R. L., A. Tanskanen, M. Chen, J. L. Greenstein (2006). "Multiscale modeling of calcium signaling in the cardiac dyad." Ann N Y Acad Sci, 1080: 362-75.

Greenstein J. L., R. Hinch, R. L. Winslow (2006). "Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte." Biophys J., 90(1): 77-91.

Hinch R., J. L. Greenstein, R. L. Winslow (2005). "Multi-Scale Models of Local Control of Calcium Induced Calcium Release." Prog Biophys & Mol Biol, 90(1-3): 136-150.

Winslow R. L., S. Cortassa, J. L. Greenstein (2005). "Using Models of the Myocyte for Functional Interpretation of Cardiac Proteomic Data." J. Physiol., 563(1): 73-81.

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