Sonia Cortassa
Research Associate, Institute of Molecular Cardiobiology and the Center for Computational Medicine and Biology, Johns Hopkins School of Medicine
Address:
844 Ross Building, Room 915
720 Rutland Avenue
Baltimore, MD 21205
Phone: (410) 955-2759
Fax: (410)
955-7953
E-mail: scortas1@jhmi.edu
CV
Research Interest Statement
Sonia Cortassa is interested in the general role of Bioenergetics in cellular function. The contribution of bioenergetics in the context of the interactions between cellular processes of different nature like electrical, mechanical and biochemical has been the focus of her studies. In particular she is addressing the interaction between energetic metabolism and EC-coupling in heart cells during normal and disease states.
Another related topic of interest is the organization of cellular metabolism and the effects of compartmentation and channeling.
To address those subjects she uses a combined experimental-theoretical approach with special emphasis on the quantitative aspects that include mathematical modeling, Metabolic Control Analysis and stability and bifurcation analysis.
Publications
Cortassa S., M. A. Aon, B. O'Rourke, R. Jacques, H. J. Tseng, E. Marban, R. L. Winslow (2006). "A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte." Biophys J., 91(4): 1564-1589.
Winslow R. L., S. Cortassa, J. L. Greenstein (2005). "Using Models of the Myocyte for Functional Interpretation of Cardiac Proteomic Data."
J. Physiol., 563(1): 73-81.
Cortassa S., M. A. Aon, R. L. Winslow, B. O'Rourke (2004). "A mitochondrial oscillator dependent on reactive oxygen species."
Biophys J., 87(3): 2060-2073.
Cortassa S., M. A. Aon, E. Marban, R. L. Winslow, B. O'Rourke (2002). "An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics."
Biophys J., 84(4): 2734-2755.
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Presentations
Calcium and ADP-mediated signaling of mitochondrial energy supply in a virtual cardiac myocyte model. BMES 2005 Annual Fall Meeting. Baltimore, MD, September 29, 2005
Calcium and ADP-mediated signaling of mitochondrial energy supply in an EC coupling-mitochondrial energetics model. Symposium on Computational Modeling of Cardiac Energetics. Oxfordshire, UK, June 29- July 1, 2005.
An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Gordon Research Conference on Cardiac Regulatory mechanisms. 2002, Abstract selected for oral presentation.
Metabolic and cellular engineering: A meeting place of molecular biology, biochemistry and physiology. Department of Biological Sciences, University of Maryland Baltimore County. November 2001.
Un enfoque dinámico del estudio de la organización en biología. Cátedra de Histología, Embriología y Genética, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Julio 1998.
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